SOLUTIONS

Cation Exchange

TSKgel Cation Exchange Chromatography Columns

Very efficient chromatography can be achieved with the nonporous TSKgel STAT columns due to the novel bonding chemistry and the absence of micro-pores. Applications for the TSKgel CM-STAT and TSKgel SP-STAT columns include the separation of proteins, protein aggregates,charge variants of monoclonal antibodies, PEGylated proteins, and peptide digests.

The pore structure and bonding chemistry of TSKgel BioAssist S columns provides high capacity for medium to large molar mass proteins.

TSKgel CM-5PW and TSKgel SP-5PW columns are an excellent choice for analyzing biologically active molecules.

TSKgel SP-NPR nonporous columns are used for the separation and analysis of proteins and peptides. They are particularly useful for adeno-associated viruses and other large macromolecules.

TSKgel CM-2SW and TSKgel SP-2SW (both 5 µm, 12.5 nm) and TSKgel CM-3SW (10 µm, 25 nm) are available for analyzing smaller molar mass samples such as nucleotides, drug candidates, catecholamines, and small peptides or proteins.

TSKgel SCX columns are used for the separation and analysis of organic acids, saccharides and alcohols.


Base Material:
polymethacrylate 
Particle Size (mean):
7 µm and 13 µm
Pore Size (mean):
130 nm
Functional Group:
sulfopropyl
Counter Ion:
Na+
pH Range:
2.0 - 12.0
Capacity (gamma globulin):
70
Small Ion Capacity:
0.1 meq/mL 
pKa:
2.4

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Base Material:
spherical silica 
Particle Size (mean):
5 µm
Pore Size (mean):
12.5 nm
Functional Group:
-CH2COO-
Counter Ion:
 Na+
pH Range:
2.0 - 7.5
Capacity (mg Hb/mL):
110
Small Ion Capacity:
> 0.3 meq/mL 
pKa:
4.2

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Base Material:
spherical silica 
Particle Size (mean):
10 µm
Pore Size (mean):
25 nm
Functional Group:
-CH2COO-
Counter Ion:
Na+
pH Range:
2.0 - 7.5
Capacity (mg Hb/mL):
ND
Small Ion Capacity:
> 0.3 meq/mL 
pKa:
4.2

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Base Material:
hydroxylated methacrylic polymer
Particle Size (mean):
10 µm and 13 µm
Pore Size (mean):
100 nm
Functional Group:
-CH2COO-
Counter Ion:
 Na+
pH Range:
2.0 - 12.0
Capacity (mg Hb/mL):
45
Small Ion Capacity:
> 0.1 meq/mL 
pKa:
4.2

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Base Material:
hydroxylated polymer
Particle Size (mean):
7 µm and 10 µm
Pore Size (mean):
non-porous
Functional Group:
carboxymethyl
Counter Ion:
 Na
pH Range:
3.0 - 10.0
Static Binding Capacity
(mg Lysozyme/g dry gel):
ca. 20 (7 µm)
ca. 15 (10 µm)
Small Ion Capacity:
100 µeq/g dry gel
pKa:
4.9
Hardware:
stainless steel
tubing and fittings, PEEK frits

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Base Material:
PS-DVB
Particle Size (mean):
5 µm
Pore Size (mean):
6.0 nm
Functional Group:
sulfonic acid
Counter Ion:
 H+ and Na+
pH Range:
2.0 - 12.0
Small Ion Capacity:
>1.5 meq/mL

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Base Material:
spherical silica
Particle Size (mean):
5 µm
Pore Size (mean):
12.5 nm
Functional Group:
sulfopropyl
Counter Ion:
 Na+
pH Range:
2.0 - 7.5
Capacity
(mg Hb/mL):
ND
Small Ion Capacity:
> 0.3 meq/mL
pKa:
2.2

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Base Material:
hydroxylated methacrylic polymer
Particle Size (mean):
10, 13, 20 µm
Pore Size (mean):
100 nm
Functional Group:
-(CH2)SO3-
Counter Ion:
 Na+
pH Range:
2.0 - 7.5
Capacity (mg Hb/mL):
40
Small Ion Capacity:
> 0.1 meq/mL
pKa:
2.3

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Base Material:
hydroxylated methacrylic polymer
Particle Size (mean):
2.5 µm
Pore Size (mean):
non-porous
Functional Group:
-(CH2)SO3-
Counter Ion:
 Na+
pH Range:
2.0 - 12.0
Capacity (mg Hb/mL):
5
Small Ion Capacity:
> 0.1 meq/mL
pKa:
2.3

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Base Material:
polymethacrylate
Particle Size (mean):
7 µm and 13 µm
Pore Size (mean):
130 nm
Functional Group:
sulfopropyl
Counter Ion:
 Na+
pH Range:
2.0 - 12.0
Capacity
(mg Hb/mL):
70
Small Ion Capacity:
> 0.1 meq/mL
pKa:
2.4

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