SOLUTIONS

Oligonucleotides

Oligonucleotides

Various approaches evaluate the use of oligonucleotides as therapeutics, ranging from antisense RNA, over siRNA to aptamers and spiegelmers. Tosoh Bioscience offers a variety of (U)HPLC columns for oligonucleotide analysis and TOYOPEARL and TSKgel media for the purification of oligonucleotides.

 


TSKgel columns are used in a broad range of typical analysis in R&D and production of oligonucleotides: 
Reversed Phase analysis of nucleic acids »  
Size Exclusion analysis of nucleic acids »  
Fast Ion Exchange analysis of impurities »  

 


TOYOPEARL and TSKgel media are typically applied in anion exchange steps of oligonucleotide purification schemes: 
High efficiency separation from (N+1) and (N-1) impurities »
High throughput separation from (N+1) and (N-1) impurities »