3
introduction
New product creation
Tosoh Bioscience and our parent, Tosoh Corporation,
provide solutions for today’s biological purification needs.
The “Custom Resin” section of this catalog describes how
we are ready to solve future separation challenges as well.
Whether it is a surface modification of an existing product
or the creation of a new resin, we encourage you to contact
us to provide you with a customized solution.
The skills toolbox
The science of biopurification is one of the fastest growing
technologies in the world. Companies that accept the pace
and are flexible will win. At Tosoh, we engineer: particle size,
pore size, surface area, ligand chemistry, and innovation.
The “Tosoh Resin Innovation Program” (TRIP) discussed in
the “Custom Resin” section of this catalog describes our
core technologies for solving customer problems.
Customer trust is our No.1 priority
Customer trust is earned, not given. Since 1987, Tosoh
Bioscience has helped develop processes from benchtop
discovery to multi-thousand liter manufacturing scale.
A number of our process customers have been with us
continuously for over 20 years. We have earned their trust.
From development to new product launch we share in the
excitement of our customers’ successes, as well as their
clinical disappointments. In either case, Tosoh Bioscience
uses its technology, innovation, and customer commit-
ment to expedite the development process to build better
customer relationships and trust for the future.
The best experience for our customers
As your manufacturing partner we want our logistical
support to be seamless to you. From your initial product
evaluation to full scale manufacturing, our technical
support, order administration, and final shipment proce-
dures are in place to make your experience with us a thor-
oughly enjoyable one.
Courteous professionals are available to answer all of your
questions. Our customer service processes are also in place
to deliver our resins to you as agreed. Journal references,
product specifications, samples, quotations, applications
and scale up support are all just a telephone call, email, or
mouse-click away.
Complete regulatory support
Controlled production processes and auditable manu-
facturing facilities are the regulatory requirements of our
industry. Well characterized, consistent resin products are
as important to us as your therapeutic molecules with their
known impurity profiles are to you. For this reason Tosoh
Corporation’s manufacturing site in Japan and both Tosoh
Bioscience subsidiaries in the US and Europe are registered
to the ISO 9001 standard.
Our manufacturing facilities are continuously audited by
customers and we pass their tests.
We maintain regulatory support information on our chro-
matographic resins available to our customers for their
process registration needs.
Comprehensive technical support
Do you need help developing an HPLC assay for the anal-
ysis of a new therapeutic target? How about monitoring
the therapeutc’s metabolites in the human body? Do you
need help with a “self-packing” process column or a multi-
thousand liter one? Our technical support specialists can
provide assistance in all of these areas and more.
We offer on-site training, application specific seminars,
and are the sole sponsor of the HIC/RPC Bioseparation
Conference series
).
The Products Toolbox
From the research laboratory to full scale manufacturing,
we offer the same polymer chemistries in our TSKgel and
TOYOPEARL products. Whether you are scaling up from
a TSKgel column HPLC method to TOYOPEARL resin for
manufacturing, or are scaling down from a TOYOPEARL
resin purification to the corresponding TSKgel column for
the QC of your target, we make it easy to develop methods
to do both.
TSKgel columns
Our TSKgel prepacked columns for high performance
liquid chromatography are used for the analysis and puri-
fication of proteins, peptides, biopolymers and low molec-
ular weight compounds. Many different chromatographic
modes are offered including: size exclusion, ion exchange,
hydrophobic interaction, hydrophilic, reversed phase,
affinity, and normal phase chromatography.
The column packing materials are either spherical silica
or polymer particles, ranging in size from 2 µm to 30 µm.
Columns are constructed of stainless steel, glass, or poly-
etheretherketone (PEEK) and are available from micro-
bore to preparative sizes. Please see our website for more
information.
Introduction
