Tosoh
customer magazine
Yifan Pang and coworkers applied the EcoSEC compact GPC system to
analyze AG/Polymer Nanaocomposites[1]. Nanocomposite materials
consist of polymer and inorganic nanoparticles (NPs) especially noble
metal NPs have shown valuable application in various fields. One ex-
ample is the antibacterial grafting of cotton materials. Of them Na-
nocomposites containing silver NPs have received intensive research
interest for its unique features in the fields of catalysis, antimicrobial
agents, conducting materials and sensors.
The authors describe a novel synthetic strategy for microspheres and
micro-plates of Ag/POA nanocomposites in the absence of solvent
and surfactant. The method combines the nucleation of Ag nanopar-
ticles and the polymerization of monomer in a facile one-pot reaction,
which provides a novel way for metal-polymer microsphere nano-
composite with low-cost, easy-operation and high-yield. The molecu-
lar weights of the products were measured by GPC on a EcoSEC GPC
System system at 40 °C with THF as mobile phase.
Dario Venetz and coauthors used TSKgel HILIC columns to analyze
the Glycosylation profile of armed antibodies [2]. Therapeutic anti-
bodies represent the largest and fastest growing class of biopharma-
ceuticals. There is a trend in moving from intact antibodies towards
“armed” antibody products, in which the antibody moiety serves as
pharmacodelivery vehicle. The impact of glycosylation on the targe-
ting performance of armed antibodies is still largely unknown.
The article sheds light on the surprising finding that relatively small
variations in glycostructures and sialic acid content can have drama-
tic effects on therapeutic agent performance. By performing detailed
biodistribution studies with a novel IL9-armed cancer-specific antibo-
dy, the authors identified a clear correlation between N-linked glycan
structures and tumor-targeting efficiencies.
Of Silver/Polymer Nanocomposites and Armed
Antibodies
Our chromatography column, media, and instrument brands - TSKgel, TOYOPEARL, and EcoSEC - are frequently menti-
oned in scientific articles. Today we picked two very interesting examples published this year. They present results
in two really diverging fields of research and application: polymer characterization on one site and research on
armed antibodies on the other site.
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TSKgel/EcoSEC
IN THE LITERATURE
[1] Pang, Y. et al.
Unexpected in-situ Free Radical Generation
and Catalysis to Ag/polymer Nanocomposite. Sci. Rep. 5, 11993; doi:
10.1038/srep11993 (2015).
[2] D. Venetz, et al.
Glycosylation Profiles determine extravasation
and disease-targeting properties of armed antibodies, PNAS 112.7: 2000-
2005; 10.1073/pnas1416694112 (2015)
