Tosoh bioscience
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MIXED-MODE
chromatography
MIXED-MODE PRODUCTS
TOYOPEARL MX-Trp-650M
Mixed-mode or multimodal chromato-
graphy, refers to chromatographic
methods that utilize more than one form
of interactions between the stationary
phase and analytes in order to achieve
their separation. Before mixed-mode was
considered as a chromatographic approach,
secondary interactions were believed
to be the main cause of peak tailing.
However, it was discovered afterwards
that secondary interactions can be applied
for improving separation power. Tosoh
Bioscience developed a high capacity
mixed-mode resin mainly for purification of
monoclonal antibodies and other proteins.
The multimodal resin maintains dynamic
binding capacity (DBC) at elevated feedstock
or buffer conductivities.
TOSOH FACT
