A Liquid Chromatography Experience from Lab to Production
At analytica 2024, we will take you on an interactive journey through chromatography from the laboratory to manufacturing. Meet our #ChromatographyExperts from April 9 to 12 in Munich and discover new developments in column, media, and instrumentation technology: (U)HPLC columns for advanced biopharmaceuticals, the LenSTM3 MALS-Visco dual detector for GPC as well as MCC systems and columns for lab scale purification, process development, and production.
DAR Analysis of ADCs
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The name gives it away: TSKgel® HIC ADC columns are hydrophobic interaction chromatography columns designed to analyze antibody-drug conjugates (ADCs). Tosoh has developed a new base particle to achieve exceptional separation of variably conjugated ADC variants. This next-generation non-porous particle technology makes DAR analysis more reliable and improves separation efficiency. Ask for a test column!
SEC-MALS Characterization of Biomolecules
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TSKgel UP-SW30000-LS size exclusion chromatography (SEC) columns are the latest addition to the famous TSKgel SW series and deliver outstanding low noise levels when used with advanced detection methods such as multi-angle light scattering (MALS) and mass spectrometry (MS). For MALS detection, this yields high signal-to-noise ratios and improves detection sensitivity. Detection sensitivity can be maximized when using these columns with the LenS3 MALS detector, known for its exceptionally high sensitivity for biomolecule characterization, whether coupled to HPLC or UHPLC systems of any brand. Ask for a short demo!
Polymer Characterization with Triple-Detection GPC
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The new LenS3 MALS-V dual detector is an integrated light scattering and viscometry detector. Combined with the EcoSEC Elite GPC system and TSKgel columns, LenS3 MALS-V offers a complete, cost-effective, high-performance approach for triple detection GPC. Triple detection GPC provides a wealth of structural information about polymers such as conformation, density of the backbone, presence of branching, hydrodynamic radius or radius of gyration. See how the impressive SECview software simplifies macromolecule characterization!
Biomolecule Purification
SkillPakTM columns are ready to use and specifically designed to allow the development and seamless scale-up of biomolecule purification processes. Pre-packed with TOYOPEARL, TSKgel, or Ca++Pure-HA chromatography media, SkillPak columns guarantee optimal performance and can be operated with standard low- or medium-pressure liquid chromatography systems. They are available in various dimensions - no need to pack purification columns yourself!
OctaveTM BIO is the most comprehensive and versatile multi-column chromatography (MCC) system to date. The unique modular design and added functionalities support a wide range of scales, implementations, and functionalities. The established Octave MCC technology enables process resins and buffer savings, and other tangible multi-column chromatography benefits. SkillPak BIO is the first set of pre-packed columns designed with standard shorter bed heights. They are optimal for the fast flow rates and short residence times of multi-column chromatography.
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