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Octave BIO System

OctaveTM BIO MCC System

The Octave™ BIO is the most comprehensive and versatile multi-column chromatography (MCC) system for process development and proof of concept. Leveraging established Octave MCC technology from other industries and tailoring it for bioprocess use cases, these systems are designed to intensify your existing biologic purification process. The unique modular design will fit your requirements and unlock the resin savings, buffer savings, and other tangible benefits that MCC can provide.

Octave BIO System Front Photo

Benchtop system based on reliable, patented Octave technology
Specifically designed for bioseparations
Flow rates raning from 1 mL/min to 300 mL/min
Up to eight columns
Six pumps, six inlets, six outlets
User-replaceable valve block available in three channel diameters
Integrated UV, conductivity, and pH sensors (4 of each)
Gradient capabilities and single column mode with sample injector
Complete data recording and analysis
Includes ProComposer™ Method Creator and Method Wizard applications
Powerful, user-friendly, BIOController™ control system 
Dedicated pre-packed SkillPak BIO columns for MCC applications available.

Dimensions (W / D / H) 137 x 51 x 98 cm; bench top
Weight 171 kg
Power requirements 100–120/220–240 VAC, 50/60 Hz
Valve pressure At least 2 bar above process pressure
Flow rate range 1 mm valve block: up to 40 ml/min
1.6 mm valve block: up to 100 ml/min
2.4 mm valve block: up to 300 ml/min
Inlets 6
Outlets 6
Columns 1-8
Maximum operating pressure 270 psi (18.6 bar)
UV sensors 4, LED, dual wavelengths
Conductivity sensors 4, range 0–200 mS/cm
pH sensors 4, range 0–14
Pumps 6, stepper motor direct drive dual piston, PEEK™ fluid path;
self-flush pistons; accuracy +/– 3%;
available flow rate ranges 0–12, 0–36, 0–100, 0–300 ml/min
Valve block 104 pneumatic two-way valves; interchangeable
Sample injector 1; 6-port, two position, automatic actuation
External outputs 5, synched to switch, cycle, phase, method, and peak collect
Control system ProComposer (Windows PC; method authoring)
BIOController (Windows PC)

Component List

Quantity Description
1 Pump Module: cabinet with 3 levels that hold two pumps each; includes two side shelves
6 Octave BIO 12, 36, 100, or 300 Pumps: precision dual-piston pump with PEEK heads and LED display
1 Valve Module: includes valve block, pneumatic system, and sample injector
1 Display Module
1 Sensor Module: includes 4 dual-channel UV Sensors, 4 conductivity sensors, 4 pH sensors, and 1 peak collect valve
1 Drawer Module
1 Reservoir Tray
1 Windows 10 computer with monitor, keyboard, and mouse; ProComposer™ and BIOController™ software preinstalled
1 User Guide Package: includes ProComposer , BIOController, and Octave BIO System User Guides


Ordering Information

Please inquire prices at [email protected] »

P/N Description
0041100 Octave BIO System 12 mL/min Configuration
0041101 Octave BIO System 36 mL/min Configuration
0041102 Octave BIO System 100 mL/min Configuration
0041103 Octave BIO System 300 mL/min Configuration
Tosoh Bioscience GmbH
Im Leuschnerpark 4
64347 Griesheim, Germany

Tel: +49 6155-7043700
Fax: +49 6155-8357900

[email protected]