Octave PRO System

OctaveTM PRO MCC System

The Octave PRO is a GMP-ready multi-column chromatography (MCC) system for the purification of biopharmaceuticals at the clinical and commercial scale. The Octave PRO is designed for direct scale-up after process development on the Octave BIO, and both systems offer the same method-execution capabilities. The Octave PRO enables ultimate process versatility and agility to address the most challenging downstream bottlenecks.

OctavePro System

GMP-ready using reliable, patented Octave technology
Specifically designed for typical clinical and commercial scale purification processes of 2000 L bioreactors
within 1-2 shift times
Flow rates ranging from 0.1 L/min to 2.5 L/min
Up to eight columns
Six pumps, six inlets, six outlets
Single use flow path
Integrated UV, conductivity, and pH sensors (4 of each)
Complete data recording and analysis
Includes ProComposer™ Method Creator and Method Wizard applications
21 CFR Part 11 compliant PROController™ control system
Dedicated SkillPak PRO pre-packed columns for MCC applications are available

Ordering Information

Please inquire [email protected] »

0041201 Octave PRO EU, Octave PRO GMP ready multi-column chromatography skid for EU region
0041202 Octave PRO SU Flowkit, Full single-use flowkit for the Octave PRO
Dimensions (W / D / H)  213 / 115 / 219 cm, (198 cm without alarm tower)
Weight 450 kg
Operating flow rate 1 – 150 L/hr (2.5 L/min)
Maximum operating pressure 6 bar (87 psi)
Valve Pressure 8 bar (116 psi)
Gas inlet pressure 9 bar (130 psi)
Column Positions/ Connections 1 to 8 columns, ¾ in. sanitary clamps
Valve block 1 single-use assembly containing 104 pneumatic two-way valves
Inlet number 6
Outlet number 6
Pumps 4-piston-diaphragm pump, flow rate ranges 1-150 L/h
Flowmeters 6; 1 after each pump, fl ow rate ranges 0.01-8 L/min
Pressure sensors 6; 1 after each pump, measuring range 1-10 bar
Outlet sensors 4 assignable single-use combination UV/ conductivity/ pH
UV sensors UV 280 nm & 305 nm
Conductivity sensors CND range 0–850 mS/cm
pH sensors pH range 0-14

Component wetted materials
Pump Head polypropylene (PP), thermoplastic elastomer (TPE), ethylene propylene diene monomer (EPDM)
Pressure Adapter PP, TPE
Flow Sensor PP
Valve Block Assembly USP class VI compliant polyetherimide (PEI), polyvinylidene fluoride (PVDF), polyfluoroalkoxy (PFA)
Optical/Conductivity/pH flow cell  quartz (UV-transparent), EPDM, stainless steel 1.4435 (SS 316L), polyphenylsulfone (PPSU)
Fittings PEEK, platinum cured silicone, PP
Tubing ¼ in. ID polybraided platinum cured silicone, pump inlet is weldable ¼ in. ID Advantaflex biopharmaceutical grade thermoplastic elastomer (TPE)
Gamma irradiation dose 25-40 kGy
Item Description
Inlet Connections 6 Aseptiquik®G
Outlet Connections 6 Aseptiquik®G
Pumps 6 Quattroflow® EZ-Set Pump Chamber quaternary diaphragm single-use heads
Pressure sensors 6 single-use gauge tees (TS1, 1 after each pump)
Flow sensors 6 single use; ultrasonic (1 after each pump)
Parameter North America EMEA
Voltage 120V; 1 phase 220-240V; 1 phase
Amps 30A 15A
Frequency 60 Hz 50 Hz
Number of Cords 1 1
Type of Plug NEMA L5-30P, with ground Must meet local code, with ground