ProComposer Method Creator

ProComposer Method Creator

Tosoh’s ProComposer™ Method Creator is used to create or edit multicolumn continuous (SMB) chromatography and single column methods. The method files created with ProComposer on a Windows PC are transferred to Tosoh’s Octave® BIO and Octave® PRO Chromatography Systems for execution.

The ProComposer Method Wizard, a separate Microsoft Excel application, facilitates conversion of conventional batch methods to MCC processes. The Wizard provides tools to determine MCC process parameters, model and compare batch and MCC process performance, and save methods in ProComposer format.

Methods created with ProComposer can be run with any size columns matched with Tosoh’s MCC Systems. The systems scale pump flow rates based on the column dimensions entered into the BIOController™ (Octave BIO) or ProController™ (Octave PRO) user interface. 

ProCompser Method Wizard Process Graphic

ProComposer includes powerful tools to take advantage of the versatility of the Octave BIO and Octave PRO Systems for using a variety of separation approaches, chemistries, and solid phase media.

The graphical user interface provides three different views (Ribbon, Flow, P&ID) that can be animated to simulate the process. All pump, column, and sensor connections are indicated to facilitate the correct physical configuration of the instruments.

ProComposer 5-column Process View

Straightforward user inputs determine the process metrics, which are displayed in real time. The user can easily model various scenarios to optimize a method before running it by changing the input parameters. run.

Scaling a method up or down is accomplished simply by changing the Feed Volume and column dimensions

ProComposer Feed Definition

ProComposer Method Metrics

ProComposer Gradient Setup

ProComposer Process View Gradient

ProComposer supports the features unique to Octave BIO, including single column analytical mode, gradients, and injection valve.

The ProComposer application can be operated on any Windows 10 computer.