Multi-Column Chromatography

Multi-column chromatography (MCC) 

Multi-column chromatography (MCC) is an innovative downstream processing (DSP) method gaining adoption for the purification of biological targets. 

As opposed to conventional batch chromatography methods, MCC continuously processes feedstock, and in turn continuously generates purified target molecules. This is accomplished by parallel operation of multiple comparably small columns. As a result, MCC dramatically raises process productivity, which translates to resin savings of 80% or greater! 

Octave BIO Front

How it works. The art of Multi-Column Chromatography

Whether you call it simulated moving bed (SMB), continuous, multi-step, or multi-column chromatography, we at Tosoh Bioscience are your global partner to intensify your chromatography process. For over a decade, customers in various industries around the world have used Octave systems to purify their solutions.

How it works
Introduction to the Multi-column technique »
Holistic Multi-column Chromatography Solution »

Success stories: Real life applications in pharma industry

The countercurrent flow created by MCC enables extremely efficient utilization of solid and liquid phases. In single-column systems, separation actually occurs in a small portion of the column at any one time, with the rest of the column performing no function other than occupying solvent and broadening bands. With MCC, typically 50-70% of the solid phase is engaged in the separation zone, while the rest of the adsorbent material is being prepared for the next cycle of separation. Moreover, MCC provides essentially an “infinite” column bed length without the costs associated with obtaining, operating, and maintaining large single columns.

Success Stories
Benefits of MCC »
Applications »

The details: Our versatile Octave MCC systems

Get to know our Octave System solutions for either pre-GMP or GMP-ready purposes.

Octave BIO System »
Octave PRO System »

All under control: Our intuitive software packages

Our instruments are controlled by intuitive software packages, while the unified ProComposer
method-generating software package guides you from method development and proof of concept through to scale-up of highly efficient MCC processes.

The MCC software packages
Method Wizard »
ProComposer »
BIOController »